NASA Spaceline Current Awareness List #905 26 June 2020 (Space Life Science Research Results)

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor, Note: The next SPACELINE Current Awareness List will be distributed on July 10.Papers deriving from NASA support:1Bijlani S, Singh NK, Mason CE, Wang CCC, Venkateswaran K.Draft genome sequences of Sphingomonas species associated with the International Space Station.Microbiol Resour Announc. 2020 Jun 18;9(25):e00578-20. K. VenkateswaranNote: ISS results. This article may be obtained online without charge.Journal Impact Factor: 0.88Funding: “We acknowledge government sponsorship. This research was funded by 2012 Space Biology NNH12ZTT001N grant number 19-12829-26 under task order NNN13D111T awarded to K.V., which was also subcontracted to C.C.C.W. and funded a postdoctoral fellowship for S.B.”2Hupfeld KE, McGregor HR, Lee JK, Beltran NE, Kofman IS, De Dios YE, Reuter-Lorenz P, Riascos RF, Pasternak O, Wood SJ, Bloomberg JJ, Mulavara AP, Seidler RD.The impact of six and twelve months in space on human brain structure and intracranial fluid shifts.Cereb Cortex Commun. 2020 Jun 15:tgaa023. R.D. SeidlerNote: ISS results. This article may be obtained online without charge.Journal Impact Factor: Not available for this journalFunding: “This work was supported by a grant from the National Aeronautics and Space Administration (NASA; NNX11AR02G) to R.S., A.M., and J.B. Additionally, during completion of this work K.H. was supported by a National Science Foundation Graduate Research Fellowship under Grant no. DGE-1315138 and DGE-1842473 and by NIH T32-NS082128. H.M. was supported by a Natural Sciences and Engineering Research Council of Canada (NSERC) Postdoctoral Fellowships Program award.”3Jella KK, Nasti TH, Li Z, Lawson DH, Switchenko JM, Ahmed R, Dynan WS, Khan MK.Exosome-containing preparations from post-irradiated mouse melanoma cells delay melanoma growth in vivo by a natural killer cell-dependent mechanism.Int J Radiat Oncol Biol Phys. 2020 Jun 16. [Epub ahead of print] W.S. DynanJournal Impact Factor: 6.203Funding: “This work was supported by Winship Invest$ Pilot Grants to MKK and WSD. Additional support was received from an American Cancer Society Institutional Research Grant (ACS#126815-IRG-14-188-01-IRG to MKK), a Department of Radiation Oncology Pilot Grant, a Melanoma Seed Grant from Melanoma Team at Winship Cancer Institute, and awards from the US National Aeronautics and Space Administration to WSD (NNX15AD63G and 80NSSC18K1116).”4Pandiarajan M, Hargens AR.Ground-based analogs for human spaceflight.Front Physiol. 2020 Jun 23;11:716. Review. A.R. HargensNote: The review focuses on bed rest, head down tilt, dry immersion, wet immersion, and unilateral lower limb suspension. This article may be obtained online without charge.Journal Impact Factor: 3.201Funding: “This work was supported by the NASA grants NNX13AJ12G, NNX13AM89G, NNX14AP25G, NSSC19K030, and NSSC19K0409.”5Daley JM, Tomimatsu N, Hooks G, Wang W, Miller AS, Xue X, Nguyen KA, Kaur H, Williamson E, Mukherjee B, Hromas R, Burma S, Sung P.Specificity of end resection pathways for double-strand break regions containing ribonucleotides and base lesions.Nat Commun. 2020 Jun 18;11(1):3088. S. BurmaNote: This article may be obtained online without charge.Journal Impact Factor: 11.878Funding: “This study was supported by NIH grants R35 CA241801, R21 ES027154, RO1 CA197796, RO1 ES007061, RO1 CA205224, RO1 GM109645, PO1 CA092584, and P30 CA054174, by the National Aeronautics and Space Administration Award NNX16AD78G, a Team Science Grant from the Gray Foundation under the Basser Initiative, and by CPRIT REI Award RR180029.”6Yang L, Zhang X, MacKay M, Foox J, Hou Q, Zheng X, Zhou R, Huang M, Jing Z, Mason CE, Wu S.Identification of radioresponsive genes in esophageal cancer from longitudinal and single cell exome sequencing.Int J Radiat Oncol Biol Phys. 2020 Jun 16. [Epub ahead of print] C.E. MasonJournal Impact Factor: 6.203Funding: “This work was supported by the National Natural Science Foundation of China (No. 81672994), Hangzhou Agriculture and Social Developmental Research Program (No. 20172016A04), Zhejiang Provincial Foundation for Natural Sciences (No. LZ15H220001), Zhejiang Provincial Medical Scientific Research Foundation of China (No. 2015PYA009), Hangzhou Science and Technology Development Program (No. 20150733Q63) and Zhejiang Provincial Medical Scientific Research Foundation of China (No. WZJ-ZJ-1628). Furthermore, we would like to thank the Starr Cancer Consortium grants (I7-A765, I9-A9-071) and funding from the Irma T. Hirschl and Monique Weill-Caulier Charitable Trusts, Bert L and N Kuggie Vallee Foundation, the WorldQuant Foundation, The Pershing Square Sohn Cancer Research Alliance, the National Institutes of Health (1R01MH117406), TRISH (NNX16AO69A:0107, NNX16AO69A:0061), and the Leukemia and Lymphoma Society (LLS) grants (LLS 9238-16, Mak, LLS-MCL-982, Chen-Kiang) and the NSF (1840275).”7Upadhyay M, Rajagopal M, Gill K, Li Y, Bansal S, Sridharan V, Tyburski JB, Boerma M, Cheema AK.Identification of plasma lipidome changes associated with low dose space-type radiation exposure in a murine model.Metabolites. 2020 Jun 17;10(6):E252. M. Boerma, M.Boerma/NSBRI Center for Research on Cardiac, Vascular, and Acute Effects of Space RadiationNote: This article may be obtained online without charge.Journal Impact Factor: 3.303Funding: “This study was supported by a grant from the National Space Biomedical Research Institute [RE03701 through NCC 9-58] to MB and AKC and NASA [80NSSC17K0425 and 80NSSC19K0437] to MB. The authors would like to acknowledge the Metabolomics Shared Resource in Georgetown University (Washington, DC, USA) which is partially supported by NIH/NCI/CCSG grant P30-CA051008.”8Basner M, Hermosillo E, Nasrini J, Saxena S, Dinges DF, Moore TM, Gur RC.Cognition test battery: Adjusting for practice and stimulus set effects for varying administration intervals in high performing individuals.J Clin Exp Neuropsychol. 2020 Jun 15. [Epub ahead of print] M. BasnerJournal Impact Factor: 1.994Funding: “This work was funded by the National Space Biomedical Research Institute (NSBRI) through grant NBPF00012 (NASA NCC 9-58) and by the National Aeronautics and Space Administration (NASA) through grant NNX14AH98G.”9Basner M, Moore TM, Nasrini J, Gur RC, Dinges DF.Response speed measurements on the Psychomotor Vigilance Test: How precise is precise enough?Sleep. 2020 Jun 17. [Epub ahead of print] M. BasnerJournal Impact Factor: 4.571Funding: “This investigation was sponsored by NASA through NNX16AI53G, the Human Factors Program of the Transportation Security Laboratory, Science and Technology Directorate, U.S. Department of Homeland Security (FAA #04-G-010); by NIH grants R01 NR004281, R01 HL102119, and UL1 RR024134; and in part by the National Space Biomedical Research Institute through NASA NCC 9–58.”10LaGoy A, Sinnott AM, Ambarian M, Pepping G-J, Simpson RJ, Agha NH, Bower JL, Alfano CA, Connaboy C.Differences in affordance-based behaviors within an isolated and confined environment are related to sleep, emotional health and physiological parameters.Acta Astronaut. 2020 Jun 24. [Article in Press] C.A. AlfanoNote: Study participants completed 30-day missions in the NASA Human Exploration Research Analog (HERA).Journal Impact Factor: 2.482Funding: “This work was supported by the National Aeronautics and Space Administration; grant number NNX15AC13G (Principal Investigators: Alfano and Simpson).”11Prasad B, Richter P, Vadakedath N, Mancinelli R, Krüger M, Strauch SM, Grimm D, Darriet P, Chapel JP, Cohen J, Lebert M.Exploration of space to achieve scientific breakthroughs.Biotechnol Adv. 2020 Nov 1;43:107572. Review. Epub 2020 Jun 12. R. MancinelliNote: From the abstract: “The review summarizes the literature on the parameters of outer space that affect the growth and behavior of cells and organisms as well as complex colloidal systems. We illustrate an understanding of gravity-related basic biological mechanisms and enlighten the possibility to explore the outer space environment for application-oriented aspects.” This article may be obtained online without charge.Journal Impact Factor: 12.831Funding: “The Space Biology Unlimited SAS, France and Space Cargo Unlimited, Luxembourg support this work, which is highly appreciated by the authors. The authors BP, PR, ML, MK, and DG are also grateful to the German Aerospace Center DLR (Grant no. 50WB1923 and 50WB1924) for the support. SMS was supported by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brazil (CAPES). RLM was funded through NASA Cooperative agreement NNX12AD05A with the Bay Area Environmental Research Institute, USA.”______________________________________________________Other papers of interest:1Colucci S, Colaianni G, Brunetti G, Ferranti F, Mascetti G, Mori G, Grano M.Irisin prevents microgravity-induced impairment of osteoblast differentiation in vitro during the space flight CRS-14 mission.FASEB J. 2020 Jun 15. [Epub ahead of print] ISS results. This article may be obtained online without charge.2Fava M, Leuti A, Maccarrone M.Lipid signalling in human immune response and bone remodelling under microgravity.Appl Sci. 2020 Jun 23;10(12):4309. Review. ISS and parabolic flight studies are reviewed. This article belongs to the Special Issue “Advances in Space Biology: Cell Behavior in Microgravity,” available at This article may be obtained online without charge.3Gala TB, Patel N, Jain R, Jain S.A novel sole design for astronaut to stimulate lower body blood circulation.Int J Sci Res Sci Eng Technol. 2020 May-Jun;6(3):1328-35. Researchers developed a shoe with a sole that contains a roller, which stimulates blood circulation when activated by pressure. This article may be obtained online without charge. The URL goes to the table of contents for this issue; this is the 58th article, about halfway down the page.4Patel SR, Witthaus MW, Erturk ES, Rabinowitz R, Nakada SY.A history of urolithiasis risk in space.Can J Urol. 2020 Jun;27(3):10233-7. From the abstract: “We reviewed the medical literature, texts and multimedia sources regarding the careers of Dr. Abraham Cockett and Dr. Peggy Whitson and their contributions to the study of urolithiasis in space, as well as the studies in between both of their careers that helped to further characterize the risks of stone formation in space.” The article may be available without charge.5Baek KW, Jung YK, Kim JS, Park JS, Hah YS, Kim SJ, Yoo JI.Rodent model of muscular atrophy for sarcopenia study.J Bone Metab. 2020 May;27(2):97-110. Review. This article may be obtained online without charge.6Eshima H, Siripoksup P, Mahmassani ZS, Johnson JM, Ferrara PJ, Verkerke ARP, Salcedo A, Drummond MJ, Funai K.Neutralizing mitochondrial ROS does not rescue muscle atrophy induced by hindlimb unloading in female mice.J Appl Physiol (1985). 2020 Jun 18. [Epub ahead of print] Hindlimb unloading study.7Hughes JM, Castellani CM, Popp KL, Guerriere KI, Matheny RW Jr, Nindl BC, Bouxsein ML.The central role of osteocytes in the four adaptive pathways of bone’s mechanostat.Exerc Sport Sci Rev. 2020 Jul;48(3):140-8. This article may be obtained online without charge.8Li H, Zhang H, Huang G, Dou Z, Xie Y, Si J, Di C.Heavy ion radiation-induced DNA damage mediates apoptosis via the Rpl27a-Rpl5-MDM2-p53/E2F1 signaling pathway in mouse spermatogonia.Ecotoxicol Environ Saf. 2020 Sep 15;201:110831. Epub 2020 Jun 11. DE, Laurens J.Time course of sensory substitution for gravity sensing in visual vertical orientation perception following complete vestibular loss.eNeuro. 2020 Jun 19. [Epub ahead of print] From the Significance Statement: “Here we measured the contribution of vestibular and proprioceptive signals to verticality perception in macaque monkeys before and following complete vestibular lesion.” This article may be obtained online without charge.10Marouane E, Rastoldo G, El Mahmoudi N, Péricat D, Chabbert C, Artzner V, Tighilet B.Identification of new biomarkers of posturo-locomotor instability in a rodent model of vestibular pathology.Front Neurol. 2020 May 29;11:470. This article may be obtained online without charge.11Wang L, Liu J, Fan Q, Fan Z, Xu X, Li Z, Dai Z, Qu L, Li Y.Benign paroxysmal positional vertigo as a complication of 90-day head-down bed rest.Eur Arch Otorhinolaryngol. 2020 Jun 16. [Epub ahead of print] Head-down tilt bed rest study.12Shoikhedbrod M.The recovery water from urine in the life-support system of automatic spacecraft using electric field effect on the urine in the conditions of space flight.J Aerospace Eng Tech. 2020;10(1):47-53. E, Law BHY, Schmölzer GM.Does parental presence affect workload during neonatal resuscitation?Arch Dis Child Fetal Neonatal Ed. 2020 Jun 19. [Epub ahead of print] The NASA Task Load Index was used.14Zorzal ER, Campos Gomes JM, Sousa M, Belchior P, da Silva PG, Figueiredo N, Lopes DS, Jorge J.Laparoscopy with augmented reality adaptations.J Biomed Inform. 2020 Jul;107:103463. The NASA Task Load Index was used….
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