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Oxford vaccine induces immune reaction, results show
At last, some hope. Oxford University’s coronavirus vaccine is safe and produces an immune response, the first human results published today show. Initial trials on 1,077 British adults found the jab induced strong antibody and T-cell responses, which may improve further after a booster. There was found to be no serious adverse events and minor side effects could be controlled by paracetamol. Science Editor Sarah Knapton explains how the inoculation uses a common cold virus, with parts of coronavirus inserted, to act as a Trojan horse and trigger an immune response. Further testing is needed to confirm if the vaccine effectively protects against infection. Initial results came as the Government announced deals with pharmaceutical firms to produce 90 million doses of two other potential vaccines – in addition to the 100 million doses being developed by Oxford in partnership with AstraZeneca. Read on for what happens next on the route to a vaccine.
Meanwhile, separate research suggests a “game-changing” treatment for Covid-19 could cut the chance of serious illness by 80 per cent. Trials using an inhaled protein – commonly used to treat multiple sclerosis – found patients given it were more than twice as likely to recover during the treatment period than those given a placebo. Stays in hospital were cut by a third. Health Editor Laura Donnelly reports on the “very impressive” findings from a study of Southampton hospital patients.
UK suspends extradition treaty with Hong Kong
Britain has suspended its extradition treaty with Hong Kong and imposed an arms embargo on the territory over China’s national security law. Foreign Secretary Dominic Raab said the measures were a “reasonable and proportionate” response to the legislation imposed by Beijing. He told MPs the extradition treaty was being suspended “immediately and indefinitely” because of concerns new rules could allow cases to be transferred to mainland China. Earlier, Prime Minister Boris Johnson stressed there was “a balance” to be struck in the UK’s relationship with China. Follow updates and reaction in our politics liveblog. Sophia Yan reports from Beijing on how China might react to the tough stance – from economics, to human rights, to diplomacy.
Heard says Depp ‘threatened to kill me many times’
Amber Heard has alleged in court that Johnny Depp “explicitly threatened to kill me many times” and that she was afraid of him. In a remarkable first day on the witness stand, Ms Heard said her ex-husband accused her of having affairs with a string of Hollywood stars, branded her “fame-hungry” and claimed that the pair fought on their wedding night over his drug use. Izzy Lyons has the latest from the High Court, where a libel case over allegations of domestic violence is taking place.
At a glance: Latest coronavirus headlines
Mapped | Local lockdowns: Are cases rising in your area?
Outbreak | Test-and-trace centre staff ‘lax about distancing’
USA | Imported masks reportedly made in labour camps
Russia | Officials ‘received experimental vaccine in April’
Video | How to stop glasses steaming up with a mask on
Also in the news: Today’s other headlines
EU summit | Emmanuel Macron accused the prime minister of the Netherlands of taking Britain’s obstructive role at EU summits. Read how the French president’s patience snapped in tough negotiations over a massive European rescue fund. Meanwhile, ahead of trade negotiations in London this week, European fishermen told Michel Barnier to insist on EU boats fishing the same amount in UK waters as before Brexit.
Prince Philip | Duke steps out of retirement for military handover
DNA | Structure rewritten as scientists find genetic ‘towers’
Testosterone row | Trans women face women’s rugby ban
Hospital stabbing | Man, 30, charged with attempted murder
Missing dogs | Couple spend $20,000 in nine-month search
Around the world: Costa del virus
Covid-19 outbreaks in Spain and France have sparked fears of a second wave – and potential disruption for holidaymakers. Spain identified 5,695 coronavirus cases in the last week, up from 2,944 the week before. Up to 96,000 residents of three Catalan towns have been advised to stay at home and residents in Barcelona were advised to leave their home only for essential trips. In France, the health minister revealed there are up to 500 “active clusters” of Covid-19. Follow the latest in our travel liveblog.
Monday interview: Nell Dunn
‘I found Chelsea boring – nobody talked to me’ | Dominic Cavendish meets Nell Dunn, the Sixties wild child who left high society behind to become a kitchen sink chronicler. Read the full interview.
Comment and analysis
Rosa Prince | Will Boris have the guts to see crisis through?
Norman Tebbit | Moving the Lords to York is so impractical
Nick Timothy | Liberalism is destroying the Western world
Tim Stanley | 2020 is the Year of Thinking Dangerously
Telegraph View | Britain must stand up to realpolitik
Marriage Diaries | Our new lockdown love handles are a real passion killer
‘White wardrobe’ | How Norman Hartnell made the Queen Mother a style icon
Choose Your Own Adventure | Remember when you were the star of the story?
Business and money briefing
Not just any job cuts | Marks & Spencer could slash 950 roles in a bid to slim down the business, adding to the recent job loss tally in retail. The company said it will remove roles that are similar to each other to have a more flexible management structure. Laura Onita reports that staff reductions are part of a wider restructuring of the ailing retailer.
State pension | ‘Let us retire at 60 to make way for the young’
TikTok | An army of influencers deployed to lure British teens
On top of markets | Live stocks and shares updates 24 hours a day
England v West Indies | Stuart Broad made early inroads into the West Indies’ top order on day five of the second Test. Follow the latest updates from Old Trafford and expert analysis in our liveblog with Ben Bloom.
‘Thanks for the new contract’ | De Gea is going nowhere
Inside Line | Is All Blacks star Aaron Smith getting better?
Analysis | Formula One heading back to the bad old days
And finally… for this evening’s downtime
The Painted Bird | Václav Marhoul’s account of a country’s descent into depravity under Nazi Germany is so brutal that it is almost unwatchable. But how true is it? Ed Power investigates the painful history behind the most horrifying war film ever made.